Intradermal vaccinations with RNA coding for TAA generate CD8+ and CD4+ immune responses and induce clinical benefit in vaccinated patients.

@article{Rittig2011IntradermalVW,
  title={Intradermal vaccinations with RNA coding for TAA generate CD8+ and CD4+ immune responses and induce clinical benefit in vaccinated patients.},
  author={Susanne Malaika Rittig and Maik Haentschel and Katrin J. Weimer and Annkristin Heine and Martin R. A. Muller and Wolfram Brugger and Marius S. Horger and Olga Maksimovic and Arnulf Stenzl and Ingmar Hoerr and H. G. Rammensee and Tobias A. W. Holderried and Lothar Kanz and Steve Pascolo and Peter Brossart},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2011},
  volume={19 5},
  pages={
          990-9
        }
}
The aim of this phase I/II nonrandomized trial was to assess feasibility, safety as well as immunological and clinical responses of a mRNA-based vaccination in patients with stage IV renal cell cancer using granulocyte-macrophage colony stimulating factor (GM-CSF) as adjuvant. Intradermal injections of in vitro transcribed naked mRNA, which was generated using plasmids coding for the tumor-associated antigens mucin 1(MUC1), carcinoembryonic (CEA), human epidermal growth factor receptor 2 (Her-2… CONTINUE READING

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