Intradermal pregnenolone sulfate attenuates capsaicin-induced nociception in rats.

  title={Intradermal pregnenolone sulfate attenuates capsaicin-induced nociception in rats.},
  author={S Chen and Bie-Ching Liu and Chao-wei Chen and Fong-Sen Wu},
  journal={Biochemical and biophysical research communications},
  volume={349 2},
We have previously shown that the neurosteroid pregnenolone sulfate (PS) inhibits the capsaicin receptor-mediated current in rat dorsal root ganglion neurons. Here, we examined the effect of intradermal injection of PS into the rat hindpaw on capsaicin-induced nociception. Results revealed that PS co-injected with capsaicin dose-dependently inhibited the capsaicin-induced nocifensive response. In contrast, injections of PS into one hindpaw and capsaicin into the contralateral hindpaw had no… CONTINUE READING

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