Intradermal infection model for pathogenesis and vaccine studies of murine visceral leishmaniasis.

@article{Ahmed2003IntradermalIM,
  title={Intradermal infection model for pathogenesis and vaccine studies of murine visceral leishmaniasis.},
  author={Saeed Ahmed and Mar{\'i}a Colmenares and Lynn Soong and Karen Goldsmith-Pestana and Leonard E. Munstermann and Ram{\'o}n Luna Molina and Diane McMahon-Pratt},
  journal={Infection and immunity},
  year={2003},
  volume={71 1},
  pages={401-10}
}
The levels of protection found in vaccine studies of murine visceral leishmaniasis are significantly lower than for cutaneous leishmaniasis; whether this is due to the high-challenge murine model employed and/or is a consequence of differences required in tissue-specific local immune responses is not understood. Consequently, an intradermal murine model of visceral leishmaniasis has been explored. Intradermal inoculation established a chronic infection in susceptible mice which was associated… CONTINUE READING

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