Intradermal immunization improves protective efficacy of a novel TB vaccine candidate.

@article{Baldwin2009IntradermalII,
  title={Intradermal immunization improves protective efficacy of a novel TB vaccine candidate.},
  author={Susan Baldwin and Sylvie Bertholet and Maria S. Kahn and Irina Zharkikh and Gregory C. Ireton and Thomas S. Vedvick and Steven G Reed and Rhea N Coler},
  journal={Vaccine},
  year={2009},
  volume={27 23},
  pages={
          3063-71
        }
}
We have developed the Mycobacterium tuberculosis (Mtb) fusion protein (ID83), which contains the three Mtb proteins Rv1813, Rv3620 and Rv2608. We evaluated the immunogenicity and protective efficacy of ID83 in combination with several emulsion-formulated toll-like receptor agonists. The ID83 subunit vaccines containing synthetic TLR4 or TLR9 agonists generated a T helper-1 immune response and protected mice against challenge with Mtb regardless of route. The ID83 vaccine formulated with… CONTINUE READING
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