Intradermal application of nociceptin increases vascular permeability in rats: the possible involvement of histamine release from mast cells.

@article{Kimura2000IntradermalAO,
  title={Intradermal application of nociceptin increases vascular permeability in rats: the possible involvement of histamine release from mast cells.},
  author={Takemi Kimura and Kiyoyuki Kitaichi and Keiichi Hiramatsu and Mamiko Yoshida and Yasushi Ito and Hiroaki Kume and Kenichi Yamaki and Ryujiro Suzuki and Kenzo Takagi},
  journal={European journal of pharmacology},
  year={2000},
  volume={407 3},
  pages={327-32}
}
Intradermal application of nociceptin was used to investigate its in vivo effect on the inflammatory response in rats. Intradermal nociceptin (5 pmol/site-5 nmol/site) increased vascular permeability in a dose-dependent manner. The increased vascular permeability by nociceptin (5 nmol/site) was dose-dependently inhibited by the histamine H1 receptor antagonist pyrilamine (50 pmol/site-5 nmol/site). In rat peritoneal mast-cell preparation, nociceptin (10(-8)-10(-4) M) dose-dependently stimulated… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 6 times over the past 90 days. VIEW TWEETS