Intradermal Histamine Release by 3 Muscle Relaxants

@article{Robertson1983IntradermalHR,
  title={Intradermal Histamine Release by 3 Muscle Relaxants},
  author={E. Robertson and L. Booij and R. Fragen and J. Crul},
  journal={Acta Anaesthesiologica Scandinavica},
  year={1983},
  volume={27}
}
The induration and redness caused by intradermal injections of equipotent doses of atracurium, vecuronium and d‐tubocurarine were measured in six healthy, male volunteers. Atracurium and d‐tubocurarine were almost indistinguishable in their reactions. Vecuronium caused a significantly smaller response than both atracurium and d‐tubocurarine. We therefore suggest that of these three drugs, vecuronium may cause the least histamine release and is, perhaps, the drug of choice in patients with a… Expand
Comparative Cutaneous Histamine Release by Neuromuscular Blocking Agents
TLDR
Normal values of cutaneous wheal diameter following intradermal injection of six neuromuscular blocking drugs were determined and a significant variation was found between the dose-response slopes perhaps suggesting a variation in the mechanism of histamine release. Expand
No cutaneous histamine release with buprenorphine?
TLDR
The absence of histamine‐releasing activity of buprenorphine may be due to the structure of the drug resulting in its decreased basicity or to the insufficient concentration of theDrug achieved at mast cell membrane. Expand
HISTAMINE RELEASE AND CHANDONIUM IODIDE.
TLDR
D-tubocurarine revealed significant histamine releasing activity in in vivo animal experiments and high incidence of positive intradermal reaction, in human volunteers, and chandonium iodide appears to be a safe neuromuscular blocking agent. Expand
Histaminoid responses to atracurium, vecuronium and tubocurarine.
TLDR
IgE levels below 15 IU X ml-1 occurred significantly more often in females and were associated with a significantly higher incidence of cutaneous reactions after intradermal atracurium and tubocurarine and with these two agents, generalized flushing after intravenous administration was also more common in this group, relative to the normal/high IgE group. Expand
Possible histamine release after vecuronium
A reasonable compromise might be to release cricoid pressure only if there is obvious and vigorous retching and to re-apply pressure as soon as this stops. As Dr Forrester states, if active vomitingExpand
Wheal and flare responses to muscl relaxants in humans
TLDR
A hydrogenated, benzylisoquinoline-nitrogen-containing ring, present in atracurium but not in papaverine, appears to be the molecular conformation responsible for mast-cell degranulation by atracuium. Expand
Changes in the plasma histamine concentration after the administration of vecuronium bromide
TLDR
It is concluded that vecuronium up to 0.2 mg·kg−1 did not change the plasma histamine concentration in the patients having no previous history of allergy or atopic tendencies. Expand
A pharmacologic study on the histamine releasing effect of atracurium and other muscle relaxants in rat isolated ileum
TLDR
It is suggested that in clinical concentrations, the histamine releasing effect of muscle relaxants was minimal, except that of gallamine, which may release histamine event at very low concentrations. Expand
Histamine release and atracurium.
  • J. Watkins
  • Medicine
  • British journal of anaesthesia
  • 1986
TLDR
It seems apparent that, while about 30% of the population as a whole are capable of releasing such small quantities of histamine (1—2 ng ml") in response to a wide range of substances administered i.v., such release may be self-limiting and not indicative of a tendency to release harmful amounts of histamines in that individual upon further stimulus. Expand
Plasma histamine levels following atracurium
TLDR
It is concluded that atracurium has a low plasma histamine release potential and that cutaneous reactions after atracorium do not always indicate that plasma histamines levels are elevated. Expand
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Hiatamine release caused by Org‐NC 45, pancuronium, metocurine and d‐tubocurarine was determined by measuring the diameter of the redness and skin induration following the intradermal injection ofExpand
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