Intracytoplasmic growth and virulence of Listeria monocytogenes auxotrophic mutants.

  title={Intracytoplasmic growth and virulence of Listeria monocytogenes auxotrophic mutants.},
  author={H{\'e}l{\`e}ne Marquis and H. G. Archie Bouwer and David J. Hinrichs and Daniel A Portnoy},
  journal={Infection and immunity},
  volume={61 9},
The intracellular growth of several auxotrophic mutants of Listeria monocytogenes was examined in cell culture, and virulence was evaluated in mice by intravenous injection of log-phase bacteria. L. monocytogenes transposon insertion mutants requiring either uracil, phenylalanine, glycine, proline, or nicotinic acid for growth were fully virulent and grew similarly to the parental strain as shown by their growth rates in cell culture. Those requiring all three aromatic amino acids… CONTINUE READING


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