Intracystic treatments for craniopharyngioma.
@article{Steinbok2010IntracysticTF,
title={Intracystic treatments for craniopharyngioma.},
author={Paul Steinbok and Juliette Hukin},
journal={Neurosurgical focus},
year={2010},
volume={28 4},
pages={
E13
}
}Craniopharyngioma is a benign tumor histopathologically and in theory should be curable by radical resection. In practice, this tumor behaves like a chronic disease, with many issues related to the effect of the tumor itself and the various treatments on the adjacent structures, such as the pituitary stalk and gland, hypothalamus, visual apparatus, and suprasellar arteries. A multimodality approach to the management of these tumors may produce the optimal outcome, balancing disease control and…
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[Therapeutic update on the treatment of craniopharyngiomas].
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References
SHOWING 1-10 OF 57 REFERENCES
Therapeutic Role of Intracavitary Bleomycin Administration in Cystic Craniopharyngioma
- Medicine
- 1995
Craniopharyngioma is a histologically benign tumor which can be totally cured by radical surgical removal; however, such a result can only be achieved in a limited percentage of patients. The…
Intracavitary Chemotherapy of Polycystic Craniopharyngioma with Bleomycin
- MedicineActa Neurochirurgica
- 1999
A case with polycystic craniopharyngioma who was treated with stereotactic insertion of a catheter-reservoir system, drainage and intracavitary use of bleomycin is reported.
Stereotactic management of craniopharyngiomas.
- MedicineStereotactic and functional neurosurgery
- 1995
Intracavitary colloidal yttrium (90Y) was extremely effective in obtaining long-lasting disappearance of craniopharyngioma cysts and worsened panhypopituitarism in children, while it was well tolerated by teenagers and adults.
Use of bleomycin in intratumoral chemotherapy for cystic craniopharyngioma. Case report.
- MedicineJournal of neurosurgery
- 1996
A case of a gigantic cystic craniopharyngioma that was treated with intratumoral injections of bleomycin with complete regression of the lesion and improvement in both visual and endocrinological symptomatology.
Evaluation of postoperative intratumoral injection of bleomycin for craniopharyngioma in children.
- MedicineJournal of neurosurgery
- 1985
Minimal tumor excision followed by intensive injection of bleomycin into the remaining tumor as postoperative adjuvant therapy in seven children with craniopharyngioma has proven the regimen to be more advantageous than total excision.
Intracavitary therapeutic options in the management of cystic craniopharyngioma
- MedicineChild's Nervous System
- 2005
A retrospective review of the clinical trials conducted over the past 30 years with special emphasis on outcome, morbidity, and mortality shows newer options stand out as valid alternatives in the controversial management of these challenging tumors.
Intracystic bleomycin therapy for craniopharyngioma in children
- MedicineCancer
- 2007
The aim of the study was to review the Canadian experience with intracystic bleomycin therapy (ICB) and to potentially decrease morbidity associated with cystic craniopharyngioma.
Craniopharyngioma: the pendulum of surgical management
- MedicineChild's Nervous System
- 2005
A series of craniopharyngiomas are reviewed looking for variables that correlated with outcome as perceived in terms of quality of life, and the long-term effects of the radiotherapy now being employed are reviewed.
Treatment of craniopharyngiomas: the multimodality approach.
- MedicinePediatric neurosurgery
- 1994
A Multimodality Protocol for the treatment of craniopharyngiomas, where stereotactic methods are used preferentially, give long-term results not inferior to those reported when microsurgical removal…
Craniopharyngioma in children: Marseille experience
- MedicineChild's Nervous System
- 2005
Craniopharyngioma in children remains a formidable tumour, and regardless of whatever progress made in their management, the incidence of recurrences is still elevated and severe sequelae can be observed.
