Intracrine androgen biosynthesis, metabolism and action revisited

@article{Schiffer2018IntracrineAB,
  title={Intracrine androgen biosynthesis, metabolism and action revisited},
  author={Lina Schiffer and Wiebke Arlt and Karl-Heinz Storbeck},
  journal={Molecular and Cellular Endocrinology},
  year={2018},
  volume={465},
  pages={4 - 26}
}
Androgens play an important role in metabolic homeostasis and reproductive health in both men and women. Androgen signalling is dependent on androgen receptor activation, mostly by testosterone and 5α-dihydrotestosterone. However, the intracellular or intracrine activation of C19 androgen precursors to active androgens in peripheral target tissues of androgen action is of equal importance. Intracrine androgen synthesis is often not reflected by circulating androgens but rather by androgen… Expand
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