Intracranial pressures and O2 extraction in conscious sheep during 72 h of hypoxia.

@article{CurranEverett1991IntracranialPA,
  title={Intracranial pressures and O2 extraction in conscious sheep during 72 h of hypoxia.},
  author={Douglas Curran-Everett and Jun Iwamoto and Michael P Meredith and John A Krasney},
  journal={The American journal of physiology},
  year={1991},
  volume={261 1 Pt 2},
  pages={H103-9}
}
High-altitude cerebral edema may occur within several days after a rapid ascent to altitude. However, the mechanisms that produce this potentially lethal condition are unclear. This experiment assessed systemic arterial and intracranial pressures (n = 22) and cerebral blood flow per unit cerebral O2 consumption (Qc/cVo2) and cerebral O2 extraction fraction (cEo2) (n = 9) in conscious sheep before and during 72 h of normobaric hypoxia (arterial O2 tension approximately 40 mmHg, oxygen saturation… CONTINUE READING