Intracranial pressure elevation after ischemic stroke in rats: cerebral edema is not the only cause, and short-duration mild hypothermia is a highly effective preventive therapy.

@article{Murtha2015IntracranialPE,
  title={Intracranial pressure elevation after ischemic stroke in rats: cerebral edema is not the only cause, and short-duration mild hypothermia is a highly effective preventive therapy.},
  author={Lucy A. Murtha and Damian D. Mcleod and Debbie Pepperall and Sarah K. McCann and Daniel J. Beard and Amelia J. Tomkins and William J M Holmes and Christopher McCabe and I Mhairi Macrae and Neil James Spratt},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2015},
  volume={35 4},
  pages={
          592-600
        }
}
In both the human and animal literature, it has largely been assumed that edema is the primary cause of intracranial pressure (ICP) elevation after stroke and that more edema equates to higher ICP. We recently demonstrated a dramatic ICP elevation 24 hours after small ischemic strokes in rats, with minimal edema. This ICP elevation was completely prevented by short-duration moderate hypothermia soon after stroke. Here, our aims were to determine the importance of edema in ICP elevation after… CONTINUE READING

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