Intracranial hypertension in acute liver failure: pathophysiological basis of rational management.
@article{Jalan2003IntracranialHI, title={Intracranial hypertension in acute liver failure: pathophysiological basis of rational management.}, author={Rajiv Jalan}, journal={Seminars in liver disease}, year={2003}, volume={23 3}, pages={ 271-82 } }
Increased intracranial pressure (ICP) in patients with acute liver failure (ALF) remains a major cause of morbidity and mortality. Conventional methods of ammonia reduction such as the use of lactulose do not improve outcome, and metabolic substrates such as L-ornithine L aspartate may offer more promise. Mannitol remains the mainstay of therapy. An important role for cerebral hyperemia in the pathogenesis of increased ICP has led to a reevaluation of established therapies such as…
104 Citations
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