Intracranial hypertension in acute liver failure: pathophysiological basis of rational management.

@article{Jalan2003IntracranialHI,
  title={Intracranial hypertension in acute liver failure: pathophysiological basis of rational management.},
  author={R. Jalan},
  journal={Seminars in liver disease},
  year={2003},
  volume={23 3},
  pages={
          271-82
        }
}
  • R. Jalan
  • Published 2003
  • Medicine
  • Seminars in liver disease
  • Increased intracranial pressure (ICP) in patients with acute liver failure (ALF) remains a major cause of morbidity and mortality. Conventional methods of ammonia reduction such as the use of lactulose do not improve outcome, and metabolic substrates such as L-ornithine L aspartate may offer more promise. Mannitol remains the mainstay of therapy. An important role for cerebral hyperemia in the pathogenesis of increased ICP has led to a reevaluation of established therapies such as… CONTINUE READING
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