Intracranial V. cholerae Sialidase Protects against Excitotoxic Neurodegeneration

  title={Intracranial V. cholerae Sialidase Protects against Excitotoxic Neurodegeneration},
  author={Anandh Dhanushkodi and Michael P. McDonald},
  booktitle={PloS one},
Converging evidence shows that GD3 ganglioside is a critical effector in a number of apoptotic pathways, and GM1 ganglioside has neuroprotective and noötropic properties. Targeted deletion of GD3 synthase (GD3S) eliminates GD3 and increases GM1 levels. Primary neurons from GD3S-/- mice are resistant to neurotoxicity induced by amyloid-β or hyperhomocysteinemia, and when GD3S is eliminated in the APP/PSEN1 double-transgenic model of Alzheimer's disease the plaque-associated oxidative stress and… CONTINUE READING