Intracranial Self-Stimulation in Man

  title={Intracranial Self-Stimulation in Man},
  author={M. P. Bishop and S. Thomas Elder and Robert G. Heath},
  pages={394 - 396}
Intracranial self-stimulation techniques, modified for use with neuropsychiatric patients, provide data suggestive of positive and negative reinforcing properties of brief electrical stimulation to various subcortical structures of the human brain. 

The central basis of motivation: intracranial self-stimulation studies.

Studies of Neuronal Activity related to Self-Stimulation and Existing Functional Neural Systems show that self-stimulation-related activity in the brain is related to “spiking” in a number of ways.

State-dependent responses to intracranial brain stimulation in a patient with depression.

An elaborate repertoire of distinctive emotional responses that were rapid in onset, reproducible, and context and state dependent are found that provide proof of concept for personalized, circuit-specific medicine in psychiatry.

Self‐stimulation in the rabbit: An anatomical map of stimulation effects

  • A. Bruner
  • Psychology, Biology
    The Journal of comparative neurology
  • 1967
An anatomical map of brain stimulation effects in rabbits, based on lever pressing and observational data, revealed close correspondence to the findings from other species, particularly rats.

Treatment-Resistant Depression: Deep Brain Stimulation

The history and current evidence of DBS at various targets for the treatment of affective disorders and insights into the field are reviewed.

Brain circuits for the representation of subjective reward value

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Brain and Cognitive Sciences, February 2011.

Intracranial Self-Stimulation to Evaluate Abuse Potential of Drugs

Strengths of ICSS in comparison with drug self-administration include potential for simultaneous evaluation of both abuse-related and abuse-limiting effects, flexibility for use with various routes of drug administration or drug vehicles, utility for studies in drug-naive subjects as well as in subjects with controlled levels of prior drug exposure, and utility for Studies of drug time course.

The Puzzle of Pain

The literature on these three aspects of pain is reviewed, larger attention being directed to the sensory or physiological research.

Neuromodulation in psychiatric disorders.




Effects of hunger and male sex hormone on self-stimulation of the brain.

  • James L Olds
  • Psychology
    Journal of comparative and physiological psychology
  • 1958

Presented at symposium, Pleasure Integration and Behavior

    Stainless steel array

    • Recent Advances in Biological Psychiatry,
    • 1957

    316 stainless steel wire, .003 inch in diameter, with quad Teflon-coated leads and six contact points 2 mm apart

      Supported by funds provided by the Louisiana State Department of Hospitals. We thank Esther Blount, Ralph Gessner, Murray Work, and Joan Warner for valuable technical and clerical assistance