Intracranial Nonthermal Irreversible Electroporation: In Vivo Analysis

@article{Garcia2010IntracranialNI,
  title={Intracranial Nonthermal Irreversible Electroporation: In Vivo Analysis},
  author={Paulo A. Garcia and John H. Rossmeisl and Robert E. Neal and Thomas L. Ellis and John D. Olson and Natalia Henao-Guerrero and John L. Robertson and Rafael V. Davalos},
  journal={The Journal of Membrane Biology},
  year={2010},
  volume={236},
  pages={127-136}
}
Nonthermal irreversible electroporation (NTIRE) is a new minimally invasive technique to treat cancer. It is unique because of its nonthermal mechanism of tumor ablation. Intracranial NTIRE procedures involve placing electrodes into the targeted area of the brain and delivering a series of short but intense electric pulses. The electric pulses induce irreversible structural changes in cell membranes, leading to cell death. We correlated NTIRE lesion volumes in normal brain tissue with electric… 
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The group has demonstrated that IRE ablation can be performed safely, and is effective at reducing the tumor volume and associated intracranial hypertension, and allows for improvement in tumor-associated neurologic dysfunction.
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  • P. A. Garcia, J. Rossmeisl, R. Davalos
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    2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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This study addresses the challenge of defining an electric field threshold for human prostate cancer tissue and three-dimensional reconstructions of the ablation volumes were created from one week post-treatment magnetic resonance imaging (MRIs) of ten patients who completed a clinical trial.
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It is vital to understand the changes in tissue properties undergoing the electric pulses to improve numerical models and predict treatment volumes and to demonstrate the impact of accounting for these changes when modeling electric field distributions to develop treatment plans.
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Findings can aid renal IRE treatment planning under varying electrode geometries and pulse strengths, where the asymmetrical sigmoid dynamic conductivity function most accurately and precisely matched lesion dimensions.
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Short intense electric pulses surpass the capacitance of the cell membrane and leads to permeabilization [electroporation (EP)]. EP can be reversible [electrochemotherapy (ECT)] or
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High-frequency irreversible electroporation pulses can be delivered to brain tumors, including areas adjacent to critical vasculature, and are capable of producing clinically relevant volumes of tumor ablation.
The effect of small intestine heterogeneity on irreversible electroporation treatment planning.
  • M. Phillips
  • Materials Science, Medicine
    Journal of biomechanical engineering
  • 2014
TLDR
Finite element analysis and experimental results are utilized to examine the effect of NTIRE on the small intestine due to concern over collateral damage to this organ during NTIRE treatment of abdominal cancers and indicate that the electroporation parameters chosen for this study avoid thermal damage to the tissue.
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