Intracranial Hemorrhage as the Initial Manifestation of a Congenital Disorder of Glycosylation

@article{Cohn2006IntracranialHA,
  title={Intracranial Hemorrhage as the Initial Manifestation of a Congenital Disorder of Glycosylation},
  author={Ronald D Cohn and Erik A. Eklund and Amanda L Bergner and James F. Casella and S Lee Woods and Janyne E Althaus and Karin J Blakemore and Harold E. Fox and Julie E. Hoover-Fong and Ada Hamosh and Nancy E. Braverman and Hudson H. Freeze and Simeon A. Boyadjiev},
  journal={Pediatrics},
  year={2006},
  volume={118},
  pages={e514 - e521}
}
Intracranial hemorrhage in a term neonate is a rare event in the absence of an identifiable precipitating factor such as severe thrombocytopenia, mechanical trauma, asphyxia, infections, or congenital vascular malformations. Congenital disorders of glycosylation are a genetically and clinically heterogeneous group of multisystem disorders characterized by the abnormal glycosylation of a number of glycoproteins. Although bleeding caused by abnormal glycosylation of various coagulation factors is… 
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