Intracranial Biodegradable Silica-Based Nimodipine Drug Release Implant for Treating Vasospasm in Subarachnoid Hemorrhage in an Experimental Healthy Pig and Dog Model

@inproceedings{Koskimki2015IntracranialBS,
  title={Intracranial Biodegradable Silica-Based Nimodipine Drug Release Implant for Treating Vasospasm in Subarachnoid Hemorrhage in an Experimental Healthy Pig and Dog Model},
  author={Janne Koskim{\"a}ki and Miikka Tarkia and Tuula Ahtola-S{\"a}til{\"a} and Lasse Saloranta and Outi Simola and Ari-Pekka Forsback and Aki Laakso and Janek Frantz{\'e}n},
  booktitle={BioMed research international},
  year={2015}
}
Nimodipine is a widely used medication for treating delayed cerebral ischemia (DCI) after subarachnoid hemorrhage. When administrated orally or intravenously, systemic hypotension is an undesirable side effect. Intracranial subarachnoid delivery of nimodipine during aneurysm clipping may be more efficient way of preventing vasospasm and DCI due to higher concentration of nimodipine in cerebrospinal fluid (CSF). The risk of systemic hypotension may also be decreased with intracranial delivery… CONTINUE READING

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