Intracortical Multiplication of Thalamocortical Signals in Mouse Auditory Cortex

  title={Intracortical Multiplication of Thalamocortical Signals in Mouse Auditory Cortex},
  author={Ling-yun Li and Ya-tang Li and Mu Zhou and Huizhong Whit Tao and Li Zhang},
  booktitle={Nature Neuroscience},
Cortical processing of sensory information begins with the transformation of thalamically relayed signals. We optogenetically silenced intracortical circuits to isolate thalamic inputs to layer 4 neurons and found that intracortical excitation linearly amplified thalamocortical responses underlying frequency and direction selectivity, with spectral range and tuning preserved, and prolonged the response duration. This signal pre-amplification and prolongation enhanced the salience of… CONTINUE READING
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