Intracortical 6-hydroxydopamine induced an asymmetrical behavioral response in the rat.

@article{Robinson1981Intracortical6I,
  title={Intracortical 6-hydroxydopamine induced an asymmetrical behavioral response in the rat.},
  author={Robert G. Robinson and T G Stitt},
  journal={Brain research},
  year={1981},
  volume={213 2},
  pages={387-95}
}
Doses of 6-hydroxydopamine (6-OHDA) from 1 to 6 microgram injected into the right frontal cortex of rats led to spontaneous hyperactivity beginning 1 week after injection and lasting throughout the 30-day postoperative period. Identical left hemispheric injections did not elicit hyperactivity until a dose of 6 microgram was reached. Biochemical assays revealed that 6-OHDA injected into either hemisphere caused approximately the same amount of depletion of norepinephrine. These results suggest… CONTINUE READING