Intracoronary nitric oxide improves postischemic coronary blood flow and myocardial contractile function.

@article{Pabla1995IntracoronaryNO,
  title={Intracoronary nitric oxide improves postischemic coronary blood flow and myocardial contractile function.},
  author={R. Pabla and A. Buda and D. Flynn and D. Salzberg and D. Lefer},
  journal={The American journal of physiology},
  year={1995},
  volume={269 3 Pt 2},
  pages={
          H1113-21
        }
}
In the present study a novel nitric oxide (NO) donor, CAS-1609, was utilized as a means of coronary NO replenishment in a canine model of myocardial ischemia-reperfusion. Administration of CAS-1609 (1.25 mg iv) 10 min before reperfusion, followed by a 1 mg/h intracoronary infusion throughout the 4.5-h reperfusion period, resulted in significant improvement in postischemic transmural myocardial blood flow (0.66 +/- 0.09 vs. 0.37 +/- 0.08 ml.min-1.g-1 for saline vehicle, P < 0.05). Dogs receiving… Expand
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