Intracoronary mesenchymal stem cells promote postischemic myocardial functional recovery, decrease inflammation, and reduce apoptosis via a signal transducer and activator of transcription 3 mechanism.

@article{Poynter2011IntracoronaryMS,
  title={Intracoronary mesenchymal stem cells promote postischemic myocardial functional recovery, decrease inflammation, and reduce apoptosis via a signal transducer and activator of transcription 3 mechanism.},
  author={Jeffrey A. Poynter and Jeremy L. Herrmann and Mariuxi C. Manukyan and Yue Wang and Aaron M. Abarbanell and Brent R. Weil and Benjamin D Brewster and Daniel R. Meldrum},
  journal={Journal of the American College of Surgeons},
  year={2011},
  volume={213 2},
  pages={253-60}
}
BACKGROUND Signal transducer and activator of transcription 3 (STAT3) regulates myocardial apoptosis, cellular proliferation, and the immune response after ischemia/reperfusion (I/R). STAT3 is also necessary for the production of vascular endothelial growth factor (VEGF) by mesenchymal stem cells (MSCs), which are known to reduce myocardial injury after I/R. However, it remains unknown whether STAT3 is an important mediator of MSC-based cardioprotection. We hypothesized that knockout of stem… CONTINUE READING

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