Intracoronary ghrelin infusion decreases coronary blood flow in anesthetized pigs.

@article{Grossini2007IntracoronaryGI,
  title={Intracoronary ghrelin infusion decreases coronary blood flow in anesthetized pigs.},
  author={Elena Grossini and Claudio Molinari and David A. S. G. Mary and Ezio Ghigo and Gianni Bona and Giovanni Vacca},
  journal={Endocrinology},
  year={2007},
  volume={148 2},
  pages={806-12}
}
The peptide ghrelin has been linked to the atherosclerotic process and coronary artery disease. We planned to study, for the first time, the primary effects of ghrelin on the intact coronary circulation and determine the mechanisms involved. In 24 sodium pentobarbitone-anesthetized pigs, changes in anterior descending coronary blood flow caused by intracoronary infusion of ghrelin at constant heart rate and arterial pressure were assessed using electromagnetic flowmeters. In 20 pigs… CONTINUE READING

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