Intracoronary fibrinolytic therapy in acute myocardial infarction. Report of a prospective randomized trial.

@article{Khaja1983IntracoronaryFT,
  title={Intracoronary fibrinolytic therapy in acute myocardial infarction. Report of a prospective randomized trial.},
  author={Fareed Khaja and Joseph A. Walton and James Brymer and Eng H. Lo and L E Osterberger and William W O'neill and Harry T. Colfer and Robert Weiss and Tain Lee and Thomas Kurian and Andrew D Goldberg and Bertram Pitt and Sidney Goldstein},
  journal={The New England journal of medicine},
  year={1983},
  volume={308 22},
  pages={1305-11}
}
We performed a randomized trial comparing intracoronary administration of streptokinase versus dextrose placebo within six hours after the onset of symptoms of acute myocardial infarction in 40 patients. The base-line clinical, hemodynamic, and angiographic findings were similar in the control and streptokinase-treated groups. Reestablishment of flow occurred in 12 of 20 patients treated with streptokinase and in 2 of 20 given placebo (P less than 0.05). Left ventricular function, angiographic… CONTINUE READING

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