Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial

@article{Wollert2004IntracoronaryAB,
  title={Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial},
  author={Kai C. Wollert and Gerd Peter Meyer and Joachim Lotz and Stefanie Ringes Lichtenberg and Peter Lippolt and Christiane Breidenbach and Stephanie Fichtner and Thomas Korte and Burkhard Hornig and Diethelm Messinger and Lubomir Arseniev and Bernd Hertenstein and Arnold Ganser and Helmut Drexler},
  journal={The Lancet},
  year={2004},
  volume={364},
  pages={141-148}
}

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Intracoronary bone marrow cell transfer after myocardial infarction: 5-year follow-up from the randomized-controlled BOOST trial.

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Intracoronary autologous mononucleated bone marrow cell infusion for acute myocardial infarction: results of the randomized multicenter BONAMI trial.

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Intracoronary autologous BMC transfer improves echocardiographic parameters of diastolic function in patients after AMI.
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References

SHOWING 1-10 OF 29 REFERENCES

Repair of Infarcted Myocardium by Autologous Intracoronary Mononuclear Bone Marrow Cell Transplantation in Humans

These results demonstrate for the first time that selective intracoronary transplantation of autologous, mononuclear BMCs is safe and seems to be effective under clinical conditions.

Bone marrow cells regenerate infarcted myocardium

It is indicated that locally delivered bone marrow cells can generate de novo myocardium, ameliorating the outcome of coronary artery disease.

Adult stem cell therapy in perspective.

Available information about cardiovascular stem cell therapy is reviewed, early experience in this new field is shared, and future directions are speculated about about future directions.

Comparison of angioplasty with stenting, with or without abciximab, in acute myocardial infarction.

Stent implantation (with or without abciximab therapy) should be considered the routine reperfusion strategy in experienced centers and when used in combination with PTCA, coronary stenting and platelet glycoprotein IIb/IIIa inhibitors may further improve outcomes.

Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts

Results indicate that haematopoietic stem cells do not readily acquire a cardiac phenotype, and raise a cautionary note for clinical studies of infarct repair.

Bone marrow-Derived Cells Do Not Incorporate Into the Adult Growing Vasculature

The findings suggest that in the adult organism, bone marrow-Derived cells do not promote vascular growth by incorporating into vessel walls but may function as supporting cells.