Intracoronary, adenovirus-mediated Akt gene transfer in heart limits infarct size following ischemia-reperfusion injury in vivo.

@article{Miao2000IntracoronaryAA,
  title={Intracoronary, adenovirus-mediated Akt gene transfer in heart limits infarct size following ischemia-reperfusion injury in vivo.},
  author={Wenfeng Miao and Zhengyu Luo and Richard N Kitsis and Kenneth Walsh},
  journal={Journal of molecular and cellular cardiology},
  year={2000},
  volume={32 12},
  pages={2397-402}
}
BACKGROUND Previous data have shown that enhanced Akt signaling inhibits cardiac myocyte apoptosis in vitro and in vivo. To elucidate the contribution of apoptosis to the pathogenesis of the infarct, we investigated whether intra-coronary Akt gene delivery could reduce gross infarct size following ischemia/reperfusion injury. METHODS AND RESULTS Replication-defective adenoviral constructs encoding a myristoylated, constitutively-active form of Akt (myrAkt) or beta -galactosidase were… CONTINUE READING