Intracolonic glycerol induces abdominal contractions in rats: role of 5-HT3 receptors.

@article{Botella1998IntracolonicGI,
  title={Intracolonic glycerol induces abdominal contractions in rats: role of 5-HT3 receptors.},
  author={Anali Conesa Botella and Jean Fioramonti and C. Eeckhout and Lionel Bu{\'e}no},
  journal={Fundamental & clinical pharmacology},
  year={1998},
  volume={12 6},
  pages={619-23}
}
Serotonin and 5-HT3 receptors may be involved in the activation of nociceptive afferent pathways by rectal distension. In rats, intracolonic infusion of glycerol is able to trigger nociceptive inputs as evidenced by the occurrence of abdominal constrictions. This work was designed to evaluate the influence of 5-HT3 receptor antagonists on this reflex and to… CONTINUE READING