Intraclonal homogeneity of clonotypic immunoglobulin M and diversity of nonclinical post-switch isotypes in multiple myeloma: insights into the evolution of the myeloma clone.

@article{Taylor2002IntraclonalHO,
  title={Intraclonal homogeneity of clonotypic immunoglobulin M and diversity of nonclinical post-switch isotypes in multiple myeloma: insights into the evolution of the myeloma clone.},
  author={Brian J. Taylor and Julie A Pittman and Karen L. Seeberger and Michael J. Mant and T. H. Reiman and Andrew R. Belch and Linda M. Pilarski},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2002},
  volume={8 2},
  pages={502-13}
}
PURPOSE The transformation status and role of clonotypic pre-switch IgM in the evolution of malignant post-switch multiple myeloma (MM) cells is unclear. In this study, we determined the differentiation stage within the B lineage of clonotypic cells from malignant and nonclinical isotype pools by analyzing the frequency and intraclonal diversity of members within each isotype pool. RESULTS Immunoglobulin VDJ transcripts were amplified from peripheral blood cells of seven patients with a hemi… CONTINUE READING

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Persistent pre - switch clonotypic myeloma cells correlate with decreased survival . Evidence for isotype switching within the myeloma clone

  • J. E. Guikema, E. Vellenga, +4 authors N. A. Bos
  • Blood
  • 2001

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