Intraclonal heterogeneity in the in vitro daunorubicin-induced apoptosis in acute myeloid leukemia.

@article{Palucka1999IntraclonalHI,
  title={Intraclonal heterogeneity in the in vitro daunorubicin-induced apoptosis in acute myeloid leukemia.},
  author={Karolina Anna Palucka and Eva Knaust and D Xu and B Macnamara and Anna Porwit-Macdonald and Astrid Gruber and Curt Peterson and Magnus Bj{\"o}rkholm and Pavel Pisa},
  journal={Leukemia & lymphoma},
  year={1999},
  volume={32 3-4},
  pages={309-16}
}
Leukemic cells from ten patients with acute myeloid leukemia (AML) were sorted on the basis of in vitro daunorubicin (DNR) uptake. The obtained subpopulations with high and low DNR accumulation were compared with regard to induction of apoptosis, expression of bcl-2 and p53. Heterogeneous induction of apoptosis, confined to subpopulations with high DNR uptake, was observed. The size of the DNR-induced apoptotic fraction (4% to 16%) within a given AML blast population was determined by… CONTINUE READING