Intraclonal diversity in follicular lymphoma analyzed by quantitative ultradeep sequencing of noncoding regions.

@article{Spence2014IntraclonalDI,
  title={Intraclonal diversity in follicular lymphoma analyzed by quantitative ultradeep sequencing of noncoding regions.},
  author={Janice M. Spence and Andrew Abumoussa and John P. Spence and W Richard Burack},
  journal={Journal of immunology},
  year={2014},
  volume={193 10},
  pages={4888-94}
}
Cancers are characterized by genomic instability, and the resulting intraclonal diversity is a prerequisite for tumor evolution. Therefore, metrics of tumor heterogeneity may prove to be clinically meaningful. Intraclonal heterogeneity in follicular lymphoma (FL) is apparent from studies of somatic hypermutation (SHM) caused by activation-induced deaminase (AID) in IGH. Aberrant SHM (aSHM), defined as AID activity outside of the IG loci, predominantly targets noncoding regions causing numerous… CONTINUE READING
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