Intracisternal injection of inflammatory soup activates the trigeminal nerve system.

@article{Hoffmann2009IntracisternalIO,
  title={Intracisternal injection of inflammatory soup activates the trigeminal nerve system.},
  author={Jan Hoffmann and Lars Neeb and Heike Israel and Frits Dannenberg and F Triebe and Ulrich Dirnagl and Uwe Reuter},
  journal={Cephalalgia : an international journal of headache},
  year={2009},
  volume={29 11},
  pages={1212-7}
}
The release of calcitonin gene-related peptide (CGRP) and sensitization of the trigeminal nerve system are important elements in migraine pathophysiology. Sensitization can be induced by topical meningeal administration of inflammatory soup (IS). CGRP release is a marker of trigeminal nerve activation. We examined the effect of intracisternal IS administration on CGRP release in rat jugular vein blood at baseline, 2 and 15 min after the beginning of IS infusion. IS administration caused a… CONTINUE READING
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