Intrachromosomal looping is required for activation of endogenous pluripotency genes during reprogramming.

  title={Intrachromosomal looping is required for activation of endogenous pluripotency genes during reprogramming.},
  author={He Zhang and Weiwei Jiao and Lin Sun and Jiayan Fan and Mengfei Chen and Hong Wang and Xiaoyi Xu and A-dong Shen and Tao Li and Beibei Niu and Shengfang Ge and Wei Li and Jiuwei Cui and Guanjun Wang and Jingnan Sun and Xianqun Fan and Xiang Hu and Randall J. Mrsny and Andrew R Hoffman and Ji-Fan Hu},
  journal={Cell stem cell},
  volume={13 1},
Generation of induced pluripotent stem cells (iPSCs) by defined factors is an extremely inefficient process, because there is a strong epigenetic block preventing cells from achieving pluripotency. Here we report that virally expressed factors bound to the promoters of their target genes to the same extent in both iPSCs and unreprogrammed cells (URCs). However, expression of endogenous pluripotentcy genes was observed only in iPSCs. Comparison of local chromatin structure of the OCT4 locus… CONTINUE READING
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Intrachromosomal Looping Is Required for Activation of Endogenous Pluripotency Genes during Reprogramming

  • Zhang
  • Cell Stem Cell (2013),
  • 2013
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