Intrachromosomal amplification of chromosome 21 (iAMP21) may arise from a breakage-fusion-bridge cycle.

@article{Robinson2007IntrachromosomalAO,
  title={Intrachromosomal amplification of chromosome 21 (iAMP21) may arise from a breakage-fusion-bridge cycle.},
  author={Hazel M. Robinson and Christine J Harrison and Anthony V Moorman and Ilse Chudoba and Jonathan C. Strefford},
  journal={Genes, chromosomes & cancer},
  year={2007},
  volume={46 4},
  pages={318-26}
}
Intrachromosomal amplification of chromosome 21 (iAMP21), involving amplification of the RUNX1 gene and duplication of chromosome 21, dup(21q), defines a new cytogenetic subgroup in B-lineage acute lymphoblastic leukemia (ALL) with a poor prognosis. Characterization of this abnormality has become vital to ensure that the most accurate detection method is used. We have previously defined common regions of amplification and deletion of chromosome 21 in these patients, although the level and… CONTINUE READING

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