Intrachromatid excision of telomeric DNA as a mechanism for telomere size control in Saccharomyces cerevisiae.

@article{Bucholc2001IntrachromatidEO,
  title={Intrachromatid excision of telomeric DNA as a mechanism for telomere size control in Saccharomyces cerevisiae.},
  author={Maria Bucholc and Yongkyu Park and Arthur J. Lustig},
  journal={Molecular and cellular biology},
  year={2001},
  volume={21 19},
  pages={6559-73}
}
We have previously identified a process in the yeast Saccharomyces cerevisiae that results in the contraction of elongated telomeres to wild-type length within a few generations. We have termed this process telomeric rapid deletion (TRD). In this study, we use a combination of physical and genetic assays to investigate the mechanism of TRD. First, to distinguish among several recombinational and nucleolytic pathways, we developed a novel physical assay in which HaeIII restriction sites are… CONTINUE READING