Intracerebroventricular metformin attenuates salt-induced hypertension in spontaneously hypertensive rats.

@article{Petersen2001IntracerebroventricularMA,
  title={Intracerebroventricular metformin attenuates salt-induced hypertension in spontaneously hypertensive rats.},
  author={J\orgen S\oberg Petersen and Daniel J. Andersen and Martin S Muntzel and Nils Henrik Diemer and Niels H. Holstein-Rathlou},
  journal={American journal of hypertension},
  year={2001},
  volume={14 11 Pt 1},
  pages={
          1116-22
        }
}
The aim of this study was to examine the effects of long-term continuous intracerebroventricular (icv) infusion of metformin on blood pressure (BP) in spontaneously hypertensive rats (SHR). To accelerate the development of hypertension, SHR were fed a 8% NaCl diet during the 3-week study period. Metformin was given in the following doses: 0 (isotonic saline; n = 7), 25 (n = 8), 50 (n = 6), 100 (n = 6), and 200 microg/day icv (n = 5). Mean arterial pressure (MAP) and heart rate (HR) were… CONTINUE READING