Intracerebroventricular injection of streptozotocin in rats produces both oxidative stress in the brain and cognitive impairment.

@article{Sharma2001IntracerebroventricularIO,
  title={Intracerebroventricular injection of streptozotocin in rats produces both oxidative stress in the brain and cognitive impairment.},
  author={Monisha Sharma and Yogendra Kumar Gupta},
  journal={Life sciences},
  year={2001},
  volume={68 9},
  pages={1021-9}
}
Recent reports suggest the involvement of free radicals in the pathophysiology of Alzheimer's disease [AD]. Streptozotocin [STZ] injection in the brain is known to cause cognitive impairment in rats and is likened to sporadic AD in humans. Though STZ is known to cause impairment in glucose and energy metabolism, it is not known whether this is associated with free radical generation. The present study was designed to investigate if the changes in learning and memory by intracerebroventricular… CONTINUE READING
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