Intracerebroventricular infusion of nerve growth factor in three patients with Alzheimer's disease.

@article{Jnhagen1998IntracerebroventricularIO,
  title={Intracerebroventricular infusion of nerve growth factor in three patients with Alzheimer's disease.},
  author={Maria Eriksdotter J{\"o}nhagen and A. Nordberg and Kaarina Amberla and Lars A B{\"a}ckman and Ted Ebendal and Bj{\"o}rn A. Meyerson and Lisa A Olson and Seiger and Masahiro Shigeta and Elvar Theodorsson and Matti H. Viitanen and Bengt Winblad and Lars Olof Wahlund},
  journal={Dementia and geriatric cognitive disorders},
  year={1998},
  volume={9 5},
  pages={246-57}
}
Nerve growth factor (NGF) is important for the survival and maintenance of central cholinergic neurons, a signalling system impaired in Alzheimer's disease. We have treated 3 patients with Alzheimer's disease with a total of 6.6 mg NGF administered continuously into the lateral cerebral ventricle for 3 months in the first 2 patients and a total of 0.55 mg for 3 shorter periods in the third patient. The patients were extensively evaluated with clinical, neuropsychological, neurophysiological and… CONTINUE READING