• Corpus ID: 23419389

Intracerebroventricular endothelin-1 (ET-1) produces Ca(2+)-mediated antinociception in mice.

@article{Nikolov1992IntracerebroventricularE,
  title={Intracerebroventricular endothelin-1 (ET-1) produces Ca(2+)-mediated antinociception in mice.},
  author={Rumen Nikolov and J E Maslarova and Irina Semkova and Slavianka G Moyanova},
  journal={Methods and findings in experimental and clinical pharmacology},
  year={1992},
  volume={14 3},
  pages={
          229-33
        }
}
Intracerebroventricular (i.c.v.) administration of endothelin-1 (ET-1) at doses of 0.313, 0.625, 1.25, 2.5 and 5 pmol/mouse produced a strong antinociceptive effect as evaluated by hot plate method in mice. The effect was dose-dependent and lasted for more than 120 min. The opioid receptor antagonist naloxone did not antagonize, and the cyclooxygenase inhibitors indomethacin and diclofenac slightly inhibited the ET-1 effect. The calcium overload blocker cinnarizine antagonized the… 
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Results indicate that sulfisoxazole, an ETA receptor antagonist, potentiates the analgesic effect of clonidine, which could be mediated through I1-imidazoline receptors and opioid receptors.
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