Intracerebroventricular administration of interleukin-1 to mice alters investigation of stimuli in a novel environment

@article{Spadaro1990IntracerebroventricularAO,
  title={Intracerebroventricular administration of interleukin-1 to mice alters investigation of stimuli in a novel environment},
  author={F Spadaro and Adrian J. Dunn},
  journal={Brain, Behavior, and Immunity},
  year={1990},
  volume={4},
  pages={308-322}
}
The behavior of mice administered recombinant interleukin-1 (IL-1) was observed in a novel multicompartment chamber. Doses of human IL-1 alpha (4 pg to 40 ng) injected intracerebroventricularly (ICV) 20 min before testing significantly reduced the mean time mice spent in contact with novel stimuli. No other behavior scored (locomotor activity, grooming, scratching) was significantly affected. Similar results were obtained with murine IL-1 alpha (770 pg or 77 ng) and hIL-1 beta (1 pg to 10 ng… CONTINUE READING

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