Intracerebroventricular administration of metformin inhibits ghrelin-induced Hypothalamic AMP-kinase signalling and food intake.

@article{Stevanovic2012IntracerebroventricularAO,
  title={Intracerebroventricular administration of metformin inhibits ghrelin-induced Hypothalamic AMP-kinase signalling and food intake.},
  author={Darko M. Stevanovic and Kristina Janjetovi{\'c} and Maja S Misirkic and Ljubica M Vucicevic and Mirjana {\vS}umarac-Dumanovi{\'c} and Dragan V Micic and Vesna Star{\vc}evi{\'c} and Vladimir Trajkovic},
  journal={Neuroendocrinology},
  year={2012},
  volume={96 1},
  pages={24-31}
}
BACKGROUND/AIMS The antihyperglycaemic drug metformin reduces food consumption through mechanisms that are not fully elucidated. The present study investigated the effects of intracerebroventricular administration of metformin on food intake and hypothalamic appetite-regulating signalling pathways induced by the orexigenic peptide ghrelin. METHODS Rats were injected intracerebroventricularly with ghrelin (5 µg), metformin (50, 100 or 200 µg), 5-amino-imidazole-4-carboxamide 1-β-D… CONTINUE READING

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