Intracerebroventricular administration of lipopolysaccharide induces indoleamine-2,3-dioxygenase-dependent depression-like behaviors

@inproceedings{Lawson2013IntracerebroventricularAO,
  title={Intracerebroventricular administration of lipopolysaccharide induces indoleamine-2,3-dioxygenase-dependent depression-like behaviors},
  author={Marcus A. Lawson and Jennifer M. Parrott and Robert H. McCusker and Robert Dantzer and Keith W. Kelley and Jason C. O’Connor},
  booktitle={Journal of Neuroinflammation},
  year={2013}
}
Activation of the tryptophan degrading enzyme indoleamine-2,3-dioxygenase 1 (IDO1) is associated with the development of behavioral signs of depression. Systemic immune challenge induces IDO1 in both the periphery and the brain, leading to increased circulating and brain concentrations of kynurenines. However, whether IDO1 activity within the brain is necessary for the manifestation of depression-like behavior of mice following a central immune challenge remains to be elucidated. We… CONTINUE READING
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