Intracerebroventricular administration of GABA-A and GABA-B receptor antagonists attenuate feeding and sleeping-like behavior induced by L-pipecolic acid in neonatal chicks.

@article{Takagi2003IntracerebroventricularAO,
  title={Intracerebroventricular administration of GABA-A and GABA-B receptor antagonists attenuate feeding and sleeping-like behavior induced by L-pipecolic acid in neonatal chicks.},
  author={Tomo Takagi and Takashi Bungo and Tetsuya Tachibana and E S Saito and Shoji Saito and Izumi Yamasaki and Shozo Tomonaga and Donald Michael Denbow and Mitsuhiro Furuse},
  journal={Journal of neuroscience research},
  year={2003},
  volume={73 2},
  pages={270-5}
}
It has been demonstrated that L-pipecolic acid (L-PA), a major metabolic intermediate of L-lysine (L-Lys) in the mammalian and chicken brain, is involved in the functioning of the GABAergic system. A previous study has shown that intracerebroventricular (i.c.v.) injection of L-PA suppressed feeding and induced sleep-like behavior in neonatal chicks; however, the precise relationship between the GABAergic system and L-PA has not been clarified. In the present study, the role of the GABA-A or… CONTINUE READING

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