Intracerebroventricular administration of 26RFa produces an analgesic effect in the rat formalin test.

@article{Yamamoto2009IntracerebroventricularAO,
  title={Intracerebroventricular administration of 26RFa produces an analgesic effect in the rat formalin test.},
  author={Tatsuo Yamamoto and Rika Miyazaki and Toshihiko Yamada},
  journal={Peptides},
  year={2009},
  volume={30 9},
  pages={1683-8}
}
GPR103 is one of the orphan G protein-coupled receptors. Recently, an endogenous ligand for GPR103, 26RFa, was identified. Many 26RFa binding sites have been observed in various nuclei of the brain involved in the processing of pain such as the parafascicular thalamic nucleus, the locus coeruleus, the dorsal raphe nucleus, and the parabrachial nucleus. In… CONTINUE READING