Intracerebroventricular N-ethylmaleimide differentially reduces supraspinal opioid analgesia in mice.

@article{SnchezBlzquez1989IntracerebroventricularND,
  title={Intracerebroventricular N-ethylmaleimide differentially reduces supraspinal opioid analgesia in mice.},
  author={Pilar S{\'a}nchez-Bl{\'a}zquez and Isabel Ulibarri and J. Rodŕıguez Garz{\'o}n},
  journal={European journal of pharmacology},
  year={1989},
  volume={166 2},
  pages={193-200}
}
I.c.v. injection of 1 nmol N-ethylmaleimide (NEM) into mice interfered with opioid-induced supraspinal analgesia, as assessed in the warm water tail-flick test. This effect of NEM was long-lasting (more than 3 days), non-competitive and differentially inhibited by the opioids studied. The analgesia induced by [D-Ala2,D-Leu5]enkephalin (DADLE), [D-Ala2,Met5… CONTINUE READING