Intracerebroventricular Metformin Decreases Body Weight But Has Pro-oxidant Effects and Decreases Survival

@article{Portela2014IntracerebroventricularMD,
  title={Intracerebroventricular Metformin Decreases Body Weight But Has Pro-oxidant Effects and Decreases Survival},
  author={Lu{\'i}s Valmor Cruz Portela and Juss{\^a}nia Gnoatto and Andressa Wigner Brochier and Clarissa Branco Haas and Adriano Martimbianco de Assis and Afonso Kopczynski de Carvalho and Gisele Hansel and Eduardo R Zimmer and Jean P. Oses and Alexandre Pastoris Muller},
  journal={Neurochemical Research},
  year={2014},
  volume={40},
  pages={514-523}
}
Metformin (Met), which is an insulin-sensitizer, decreases insulin resistance and fasting insulin levels. The precise molecular target of Met is unknown; however, several reports have shown an inhibitory effect on mitochondrial complex I of the electron transport chain (ETC), which is a related site for reactive oxygen species production. In addition to… CONTINUE READING