Intracerebroventricular Administration of C-Type Natriuretic Peptide Suppresses Food Intake via Activation of the Melanocortin System in Mice

@inproceedings{YamadaGoto2013IntracerebroventricularAO,
  title={Intracerebroventricular Administration of C-Type Natriuretic Peptide Suppresses Food Intake via Activation of the Melanocortin System in Mice},
  author={Nobuko Yamada-Goto and Goro Katsuura and Ken Ebihara and Megumi Inuzuka and Yukari Ochi and Yui Yamashita and Toru Kusakabe and Akihiro Yasoda and Noriko Satoh-Asahara and Hiroyuki Ariyasu and Kiminori Hosoda and Kazuwa Nakao},
  booktitle={Diabetes},
  year={2013}
}
C-type natriuretic peptide (CNP) and its receptor are abundantly distributed in the brain, especially in the arcuate nucleus (ARC) of the hypothalamus associated with regulating energy homeostasis. To elucidate the possible involvement of CNP in energy regulation, we examined the effects of intracerebroventricular administration of CNP on food intake in mice. The intracerebroventricular administration of CNP-22 and CNP-53 significantly suppressed food intake on 4-h refeeding after 48-h fasting… CONTINUE READING
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