Intracerebral pain processing in a Yoga Master who claims not to feel pain during meditation

  title={Intracerebral pain processing in a Yoga Master who claims not to feel pain during meditation},
  author={Ryusuke Kakigi and Hiroki Nakata and Koji Inui and Nobuo Hiroe and Osamu Nagata and Manabu Honda and Satoshi Tanaka and Norihiro Sadato and Mitsumasa Kawakami},
  journal={European Journal of Pain},

Meditation reduces pain-related neural activity in the anterior cingulate cortex, insula, secondary somatosensory cortex, and thalamus

It is hypothesized that meditation reduces pain-related neural activity in the ACC, insula, secondary somatosensory cortex, and thalamus and suggested that the characteristics of the modulation of this activity may depend on the kind of meditation and/or number of years of experience of meditation.

[Mechanisms of intracerebral pain and itch perception in humans].

The findings obtained after itch stimulation were similar to those obtained after pain stimulation, but the precuneus may be an itch-selective brain region, confirmed by both MEG and fMRI studies.

Medial profrontal cortex and anterior cingulate cortex in the generation of alpha activity induced by transcendental meditation: a magnetoencephalographic study.

It is suggested that the mPFC and ACC play an important role in brain activity induced by TM, and the dipoles were mapped to both the medial prefrontal cortex (mPFC) and anterior cingulate cortex (ACC).

fMRI study of pain reaction in the brain under state of "Qigong".

The result indicated that the main manifestation of brain functional change under Qigong was functional suppressing, but in some particular regions such as SII-insula region in this study, the response amplitude was increased.


A significant reduction of pain ratings was found following both the visual and the auditory alpha stimulation across all three frequencies in Chapters 4,5 and 6, and the findings provide a solid foundation for further investigation of alpha based neuro-modulation as an analgesic intervention.

Meditation and the Brain in Health and Disease

The aim of this chapter is to provide an accessible introduction to the neuroscience of meditation. First, a review of studies examining the relationship between meditation and alterations in the

Mining the Mind: Linear Discriminant Analysis of MEG Source Reconstruction Time Series Supports Dynamic Changes in Deep Brain Regions During Meditation Sessions

MEG data collected during meditation sessions of experienced Buddhist monks practicing focused attention and open monitoring meditation are considered, and the cingulate cortex, insular cortex and some of the internal structures stand out as separating regions which seems to correlate well with earlier findings based on longitudinal studies.



Expectation of Pain Enhances Responses to Nonpainful Somatosensory Stimulation in the Anterior Cingulate Cortex and Parietal Operculum/Posterior Insula: an Event-Related Functional Magnetic Resonance Imaging Study

It is suggested that ACC and PO/PI are involved in modulation of affective aspect of sensory perception by the uncertain expectation of painful stimulus.

A 15O‐H2O PET study of meditation and the resting state of normal consciousness

It is concluded that the H215O PET method may measure CBF distribution in the meditative state as well as during the resting state of normal consciousness, and that characteristic patterns of neural activity support each state.

Effects of distraction on pain perception: magneto- and electro-encephalographic studies.

Role of Operculoinsular Cortices in Human Pain Processing: Converging Evidence from PET, fMRI, Dipole Modeling, and Intracerebral Recordings of Evoked Potentials

This multimodal study provides cross-validated spatial and temporal information on the pain-related processes occurring in the operculoinsular region, which thus appears as a major site for the early cortical pain encoding in the human brain.

Increased cerebral functional connectivity underlying the antinociceptive effects of hypnosis.

Imaging how attention modulates pain in humans using functional MRI.

Functional MRI was used to elucidate the underlying neural systems and mechanisms involved in reduced pain perception and showed brain areas associated with the affective division of the anterior cingulate cortex and orbitofrontal regions showed increased activation when subjects were distracted during painful stimulation.

Pain Processing Traced by Magnetoencephalography in the Human Brain

The temporal and spatial processing of pain perception in human was traced by MEG and the four-source model was found to be the most appropriate; sources 1 and 2 at the secondary sensory cortex (SII) contralateral and ipsilateral to the stimulation, and sources 3 and 4 at the anterior medial temporal area (probably the amygdalar nuclei or hippocampal formation).

Functional MRI study of thalamic and cortical activations evoked by cutaneous heat, cold, and tactile stimuli.

Functional magnetic resonance imaging is used to locate discrete regions of the thalamus, insula, and second somatosensory cortex modulated during innocuous and noxious thermal stimulation and provides support for a role of the anterior insula and S2 in the perception of pain; whereas the posterior insula appears to be involved in tactile and innocuous temperature perception.