Intracerebral hemorrhage models in rat: comparing collagenase to blood infusion.

Abstract

Many therapies have shown promise in preclinical stroke studies, but few benefit patients. A greater understanding of stroke pathophysiology is needed to successfully develop therapies, and this depends on appropriate animal models. The collagenase and blood infusion models of intracerebral hemorrhage (ICH) are widely used; yet, investigators often prefer… (More)

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@article{Maclellan2008IntracerebralHM, title={Intracerebral hemorrhage models in rat: comparing collagenase to blood infusion.}, author={Crystal L Maclellan and Gergely Silasi and Candice C Poon and Carmen L Edmundson and Richard Buist and James Peeling and Frederick Colbourne}, journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism}, year={2008}, volume={28 3}, pages={516-25} }