Intracerebral hemorrhage complicating intravenous tissue plasminogen activator treatment.

  title={Intracerebral hemorrhage complicating intravenous tissue plasminogen activator treatment.},
  author={Susan E. Carlson and Michael S. Aldrich and Harry S. Greenberg and Eric J. Topol},
  journal={Archives of neurology},
  volume={45 10},
Tissue plasminogen activator's thrombolytic action is relatively specific for fibrin; however, systemic bleeding can occur in patients, especially when heparin is simultaneously administered. We describe two cases of intracerebral hemorrhage from a cohort of 450 patients (0.44%) treated at one institution with tissue plasminogen activator and heparin for acute myocardial infarction. A pooled worldwide review of 5258 cases from several clinical protocols for treatment of acute myocardial… CONTINUE READING


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