Intracerebral cytokine profiles in adult rats grafted with neural tissue of different immunological disparity.

@article{Mirza2004IntracerebralCP,
  title={Intracerebral cytokine profiles in adult rats grafted with neural tissue of different immunological disparity.},
  author={Bilal Mirza and Henrik Krook and Per E. Andersson and Lena C Larsson and Olle Korsgren and H{\aa}kan Widner},
  journal={Brain research bulletin},
  year={2004},
  volume={63 2},
  pages={105-18}
}
To understand graft rejection in cell based therapies for brain repair we have quantified IL-1beta, IL-2, IL-4, IL-10, IL-12p40, IFN-gamma and TNF-alpha mRNA levels using real-time PCR, at days 4, 14, and 42 post-transplantation, in rats engrafted with syngeneic, allogeneic, concordant and discordant xenogeneic neural tissues. In addition, in the discordant xenografts immunohistochemistry and in situ hybridization were applied to detect local expression of IFN-gamma, TNF-alpha, IL-10 and TGF… CONTINUE READING
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