Intracerebral adenosine infusion improves neurological outcome after transient focal ischemia in rats.

@article{Kitagawa2002IntracerebralAI,
  title={Intracerebral adenosine infusion improves neurological outcome after transient focal ischemia in rats.},
  author={Hisashi Kitagawa and Atsushi Mori and Jun Shimada and Yasuhide Mitsumoto and Tetsuro Kikuchi},
  journal={Neurological research},
  year={2002},
  volume={24 3},
  pages={317-23}
}
Second Institute of New Drug Research, Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan In order to elucidate the role of adenosine in brain ischemia, the possible protective effects of adenosine on ischemic brain injury were investigated in a rat model of brain ischemia both in vitro and in vivo. Exogenous adenosine dose-dependently rescued cortical neuronal cells from injury after glucose deprivation in vitro. Adenosine (1 mM) also significantly reduced hypoglycemia/hypoxia-induced glutamate… CONTINUE READING

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Adenosine kinase determines the degree of brain injury after ischemic stroke in mice.

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